A Simple and Clean Method for Methoxymethylation of Phenols
A simple and clean procedure for the preparation of methoxymethyl ethers (MOM = CH2 OMe) of phenols having internally hydrogen bonded hydroxy groups is described. Thus treatment of 2,5-dihydroxybenzaldehyde (1) with a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperatur...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
1989
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| Online Access: | http://psasir.upm.edu.my/id/eprint/2614/1/A_Simple_and_Clean_Method_for_Methoxymethylation_of_Phenols.pdf http://psasir.upm.edu.my/id/eprint/2614/ |
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| Summary: | A simple and clean procedure for the preparation of methoxymethyl ethers (MOM = CH2 OMe) of phenols having
internally hydrogen bonded hydroxy groups is described. Thus treatment of 2,5-dihydroxybenzaldehyde (1) with
a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperature gives 2.5-bis(
methoxymethoxy)benzaldehyde (2) in 57% yield; under similar conditions, the methoxymethyl ether (6) of
salicylaldehyde was isolated in 75% yield. Yields of61-81 %, not optimised, of methoxymethyl ethers of several
phenols lacking internal hydrogen bonding were also obtained. |
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