Dynamics of the bacterially expressed conserved immunogenic region of the human respiratory syncytial virus G protein.
Despite all efforts, there is still no effective vaccine available against the human respiratory syncytial virus (HRSV) that is a major cause of severe lower respiratory tract disease in infants and the elderly. In this review, we examined the potential of the conserved immunogenic region (residues...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Wiley-Blackwell
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25358/1/Dynamics%20of%20the%20bacterially%20expressed%20conserved%20immunogenic%20region%20of%20the%20human%20respiratory%20syncytial%20virus%20G%20protein.pdf http://psasir.upm.edu.my/id/eprint/25358/ http://onlinelibrary.wiley.com/ |
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| Summary: | Despite all efforts, there is still no effective vaccine available against the human respiratory syncytial virus (HRSV) that is a major cause of severe lower respiratory tract disease in infants and the elderly. In this review, we examined the potential of the conserved immunogenic region (residues 122-226) of the HRSV glycoprotein G alone as the inducer of neutralizing antibodies against this virus. The Escherichia coli produced recombinant conserved region of G (designated as G domain), which was used for rabbit immunization. Although rabbit is a semipermissive host for HRSV, our result showed that the polyclonal antibodies against the G domain protein could strongly neutralize the virus (69.3%), suggesting that the G immunogenic region of HRSV alone has a great potential in vaccine development. To our knowledge, this is the first report in which neutralizing antibodies to respiratory syncytial virus have been evoked using bacterially expressed G immunogenic domain protein without any adjuvant. |
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