Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression.
Mitragyna speciosa Korth. leaves have been used for decades as a traditional medicine to treat diarrhea, diabetes and to improve blood circulation by natives of Malaysia, Thailand and other regions of Southeast Asia. Mitragynine is the major active alkaloid in the plant. To date, the role of mitragy...
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2011
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my.upm.eprints.244522015-12-10T03:34:04Z http://psasir.upm.edu.my/id/eprint/24452/ Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. Nasir, Farah Idayu Baharuldin, Mohamad Taufik Hidayat Mohd Moklas, Mohamad Aris Fakurazi, Sharida Adib Ridzuan, Nurul Raudzah Abdul Rahman, Shamima Apryani, Evhy Mitragyna speciosa Korth. leaves have been used for decades as a traditional medicine to treat diarrhea, diabetes and to improve blood circulation by natives of Malaysia, Thailand and other regions of Southeast Asia. Mitragynine is the major active alkaloid in the plant. To date, the role of mitragynine in psychological disorders such as depression is not scientifically evaluated. Hence, the present investigation evaluates the antidepressant effect of mitragynine in the mouse forced swim test (FST) and tail suspension test (TST), two models predictive of antidepressant activity and the effect of mitragynine towards neuroendocrine system of hypothalamic- pituitary-adrenal (HPA) axis by measuring the corticosterone concentration of mice exposed to FST and TST. An open-field test (OFT) was used to detect any association of immobility in the FST and TST with changes in motor activity of mice treated with mitragynine. In the present study, mitragynine at dose of 10 mg/kg and 30 mg/kg i.p. injected significantly reduced the immobility time of mice in both FST and TST without any significant effect on locomotor activity in OFT. Moreover, mitragynine significantly reduced the released of corticosterone in mice exposed to FST and TST at dose of 10 mg/kg and 30 mg/kg. Overall, the present study clearly demonstrated that mitragynine exerts an antidepressant effect in animal behavioral model of depression (FST and TST) and the effect appears to be mediated by an interaction with neuroendocrine HPA axis systems. Elsevier 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24452/1/Antidepressant-like%20effect%20of%20mitragynine%20.pdf Nasir, Farah Idayu and Baharuldin, Mohamad Taufik Hidayat and Mohd Moklas, Mohamad Aris and Fakurazi, Sharida and Adib Ridzuan, Nurul Raudzah and Abdul Rahman, Shamima and Apryani, Evhy (2011) Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. Phytomedicine, 18 (5). pp. 402-407. ISSN 0944-7113; ESSN: 1618-095X http://www.phytomedicinejournal.com/ English |
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Mitragyna speciosa Korth. leaves have been used for decades as a traditional medicine to treat diarrhea, diabetes and to improve blood circulation by natives of Malaysia, Thailand and other regions of Southeast Asia. Mitragynine is the major active alkaloid in the plant. To date, the role of mitragynine in psychological disorders such as depression is not scientifically evaluated. Hence, the present investigation evaluates the antidepressant effect of mitragynine in the mouse forced swim test (FST) and tail suspension test (TST), two models predictive of antidepressant activity and the effect of mitragynine towards neuroendocrine system of hypothalamic- pituitary-adrenal (HPA) axis by measuring the corticosterone concentration of mice exposed to FST and TST. An open-field test (OFT) was used to detect any association of immobility in the FST and TST with changes in motor activity of mice treated with mitragynine. In the present study, mitragynine at dose of 10 mg/kg and 30 mg/kg i.p. injected significantly reduced the immobility time of mice in both FST and TST without any significant effect on locomotor activity in OFT. Moreover, mitragynine significantly reduced the released of corticosterone in mice exposed to FST and TST at dose of 10 mg/kg and 30 mg/kg. Overall, the present study clearly demonstrated that mitragynine exerts an antidepressant effect in animal behavioral model of depression (FST and TST) and the effect appears to be mediated by an interaction with neuroendocrine HPA axis systems. |
format |
Article |
author |
Nasir, Farah Idayu Baharuldin, Mohamad Taufik Hidayat Mohd Moklas, Mohamad Aris Fakurazi, Sharida Adib Ridzuan, Nurul Raudzah Abdul Rahman, Shamima Apryani, Evhy |
spellingShingle |
Nasir, Farah Idayu Baharuldin, Mohamad Taufik Hidayat Mohd Moklas, Mohamad Aris Fakurazi, Sharida Adib Ridzuan, Nurul Raudzah Abdul Rahman, Shamima Apryani, Evhy Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. |
author_facet |
Nasir, Farah Idayu Baharuldin, Mohamad Taufik Hidayat Mohd Moklas, Mohamad Aris Fakurazi, Sharida Adib Ridzuan, Nurul Raudzah Abdul Rahman, Shamima Apryani, Evhy |
author_sort |
Nasir, Farah Idayu |
title |
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. |
title_short |
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. |
title_full |
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. |
title_fullStr |
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. |
title_full_unstemmed |
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. |
title_sort |
antidepressant-like effect of mitragynine isolated from mitragyna speciosa korth in mice model of depression. |
publisher |
Elsevier |
publishDate |
2011 |
url |
http://psasir.upm.edu.my/id/eprint/24452/1/Antidepressant-like%20effect%20of%20mitragynine%20.pdf http://psasir.upm.edu.my/id/eprint/24452/ http://www.phytomedicinejournal.com/ |
_version_ |
1643828365310820352 |
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13.19449 |