Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis.
Plants have not only been consumed as food but have also been adopted as folk medicine for centuries. Elephantopus scaber Linn, a herb from the Asteraceae family, has traditionally been taken as decoction or tea to cure various ailments and diseases throughout the world. Recent studies had also sugg...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English English |
Published: |
Academic Journals
2011
|
Online Access: | http://psasir.upm.edu.my/id/eprint/24135/1/Elephantopus%20scaber%20induces%20cytotoxicity%20in%20MCF.pdf http://psasir.upm.edu.my/id/eprint/24135/ http://www.academicjournals.org/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.upm.eprints.24135 |
---|---|
record_format |
eprints |
spelling |
my.upm.eprints.241352015-09-14T00:39:34Z http://psasir.upm.edu.my/id/eprint/24135/ Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. Ho, Wan Yong Yeap, Swee Keong Ho, Chai Ling Abdul Rahim, Raha Abd. Aziz, Suraini Mohamed Alitheen, Noorjahan Banu Plants have not only been consumed as food but have also been adopted as folk medicine for centuries. Elephantopus scaber Linn, a herb from the Asteraceae family, has traditionally been taken as decoction or tea to cure various ailments and diseases throughout the world. Recent studies had also suggested that this plant posses various bioactivities such as anti-bacterial, anti-inflammatory, hepatoprotective as well as anti cancer properties. In this study, the cytotoxic effect of an ethanolic extract of E. scaber on a breast cancer cell line, MCF-7 and the underlying cell death mechanism was examined. E. scaber showed cytotoxic effect towards MCF-7 cells with an IC 50 value of 15 μg/mL. In comparison to the untreated control, the extract triggered cell death with increased phosphatidylserine externalization, DNA breaks and significant morphological apoptotic characteristics in the MCF-cells. Furthermore, we also found that expression of the tumor suppressor p53 protein was up-regulated in response to the treatment. In conclusion, these results suggested that the ethanolic extract of E. scaber may be a potential anti cancer agent for human breast cancer cells by the induction of p53-dependent apoptosis. Academic Journals 2011-10-30 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24135/1/Elephantopus%20scaber%20induces%20cytotoxicity%20in%20MCF.pdf Ho, Wan Yong and Yeap, Swee Keong and Ho, Chai Ling and Abdul Rahim, Raha and Abd. Aziz, Suraini and Mohamed Alitheen, Noorjahan Banu (2011) Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. Journal of Medicinal Plants Research, 5 (24 ). pp. 5741-5749. ISSN 1996-0875 http://www.academicjournals.org/ English |
institution |
Universiti Putra Malaysia |
building |
UPM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Putra Malaysia |
content_source |
UPM Institutional Repository |
url_provider |
http://psasir.upm.edu.my/ |
language |
English English |
description |
Plants have not only been consumed as food but have also been adopted as folk medicine for centuries. Elephantopus scaber Linn, a herb from the Asteraceae family, has traditionally been taken as decoction or tea to cure various ailments and diseases throughout the world. Recent studies had also suggested that this plant posses various bioactivities such as anti-bacterial, anti-inflammatory, hepatoprotective as well as anti cancer properties. In this study, the cytotoxic effect of an ethanolic extract of E. scaber on a breast cancer cell line, MCF-7 and the underlying cell death mechanism was examined. E. scaber showed cytotoxic effect towards MCF-7 cells with an IC 50 value of 15 μg/mL. In comparison to the untreated control, the extract triggered cell death with increased phosphatidylserine externalization, DNA breaks and significant morphological apoptotic characteristics in the MCF-cells. Furthermore, we also found that expression of the tumor suppressor p53 protein was up-regulated in response to the treatment. In conclusion, these results suggested that the ethanolic extract of E. scaber may be a potential anti cancer agent for human breast cancer cells by the induction of p53-dependent apoptosis. |
format |
Article |
author |
Ho, Wan Yong Yeap, Swee Keong Ho, Chai Ling Abdul Rahim, Raha Abd. Aziz, Suraini Mohamed Alitheen, Noorjahan Banu |
spellingShingle |
Ho, Wan Yong Yeap, Swee Keong Ho, Chai Ling Abdul Rahim, Raha Abd. Aziz, Suraini Mohamed Alitheen, Noorjahan Banu Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. |
author_facet |
Ho, Wan Yong Yeap, Swee Keong Ho, Chai Ling Abdul Rahim, Raha Abd. Aziz, Suraini Mohamed Alitheen, Noorjahan Banu |
author_sort |
Ho, Wan Yong |
title |
Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. |
title_short |
Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. |
title_full |
Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. |
title_fullStr |
Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. |
title_full_unstemmed |
Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. |
title_sort |
elephantopus scaber induces cytotoxicity in mcf-7 human breast cancer cells via p53-induced apoptosis. |
publisher |
Academic Journals |
publishDate |
2011 |
url |
http://psasir.upm.edu.my/id/eprint/24135/1/Elephantopus%20scaber%20induces%20cytotoxicity%20in%20MCF.pdf http://psasir.upm.edu.my/id/eprint/24135/ http://www.academicjournals.org/ |
_version_ |
1643828270102216704 |
score |
13.18916 |