Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells

• Main Authors: Abdul Aziz, Muhammad Yusran, Omar, Abdul Rahman, Subramani, Tamilselvan, Yeap, Swee Keong, Ho, Wan Yong, Ismail, Nor Hadiani, Ahmad, Syahida, Mohamed Alitheen, Noorjahan Banu
• Format: Article
• Language: English
• Published: Spandidos Publications 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/36961/1/Damnacanthal%20is%20a%20potent%20inducer%20of%20apoptosis%20with%20anticancer%20activity%20by%20stimulating%20p53%20and%20p21%20genes%20in%20MCF.pdf; http://psasir.upm.edu.my/id/eprint/36961/; http://www.spandidos-publications.com/ol/7/5/1479/abstract

Damnacanthal, an anthraquinone compound, is isolated from the roots of Morinda citrifolia L. (noni), which has been used for traditional therapy in several chronic diseases, including cancer. Although noni has long been consumed in Asian and Polynesian countries, the molecular mechanisms by which it...