Local composition-regular solution theory for analysis of pharmaceutical solubility in mixed-solvents

• Main Authors: Lee, Jia Lin, Chong, Gun Hean, Kanno, Asami, Ota, Masaki, Guo, Haixin, Smith, Richard Lee
• Format: Article
• Language: English
• Published: Elsevier 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/106154/1/106154.pdf; http://psasir.upm.edu.my/id/eprint/106154/; https://linkinghub.elsevier.com/retrieve/pii/S0167732224000679

Local composition regular solution theory (LC-RST) model was developed by introducing non-equal i–j and j–i parameters into regular solution theory (RST) to account for specific molecular interactions. The LC-RST model was applied to the correlation of solubilities of active pharmaceutical ingredien...