Enhancing uric acid electrochemical detection with copper ion-activated mini protein mimicking uricase within ZIF-8: response surface methodology (RSM) optimization

• Main Authors: Abdul Aziz, Siti Fatimah Nur, Hui, Ong Sin, Salleh, Abu Bakar, Normi, Yahaya M., Yusof, Nor Azah, Ashari, Siti Efliza, Alang Ahmad, Shahrul Ainliah
• Format: Article
• Published: Springer 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/105881/; https://link.springer.com/article/10.1007/s00216-023-05011-z

This study aims to investigate the influence of copper(II) ions as a cofactor on the electrochemical performance of a biocomposite consisting of a mini protein mimicking uricase (mp20) and zeolitic immidazolate framework-8 (ZIF-8) for the detection of uric acid. A central composite design (CCD) was...