Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers
Acrylic monomers; Ascorbic acid; Chitosan; Controlled drug delivery; Graft copolymers; Grafting (chemical); Hydrogels; Scanning electron microscopy; Sodium; Targeted drug delivery; Acrylamides; Crosslinked; Diclofenac sodium; Drug release; Equilibration process; Fick�s law; Graft- copolymers; PH-res...
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my.uniten.dspace-269262023-05-29T17:37:51Z Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers Chopra L. Thakur K.K. Chohan J.S. Sharma S. Ilyas R.A. Asyraf M.R.M. Zakaria S.Z.S. 57422629500 57213620560 55211273900 57211422917 57196328367 57205295733 35996197700 Acrylic monomers; Ascorbic acid; Chitosan; Controlled drug delivery; Graft copolymers; Grafting (chemical); Hydrogels; Scanning electron microscopy; Sodium; Targeted drug delivery; Acrylamides; Crosslinked; Diclofenac sodium; Drug release; Equilibration process; Fick�s law; Graft- copolymers; PH-responsive; Sodium diclofenac; Sustainable drug release; Amides The hydrogels responding to pH synthesized by graft copolymerization only and then concurrent grafting and crosslinking of monomer N-isopropyl acrylamide (NIPAAM) and binary comonomers acrylamide, acrylic acid and acrylonitrile (AAm, AA and AN) onto chitosan support were explored for the percent upload and release study for anti-inflammatory diclofenac sodium drug (DS), w.r.t. time and pH. Diclofenac sodium DS was seized in polymeric matrices by the equi-libration process. The crosslinked-graft copolymers showed the highest percent uptake than graft copolymers (without crosslinker) and chitosan itself. The sustainable release of the loaded drug was studied with respect to time at pH 2.2, 7.0, 7.4 and 9.4. Among graft copolymers (without crosslink-ing), Chit-g-polymer (NIPAAM-co-AA) and Chit-g-polymer (NIPAAM-co-AN) exhibited worthy results for sustainable drug deliverance, whereas Crosslink-Chit-g-polymer (NIPAAM-co-AA) and Crosslink-Chit-g-polymer (NIPAAM-co-AAm) presented the best results for controlled/sustained release of diclofenac sodium DS with 93.86 % and 96.30 % percent release, respectively, in 6 h contact time. Therefore, the grafted and the crosslinked graft copolymers of the chitosan showed excellent delivery devices for the DS with sustainable/prolonged release in response to pH. Drug release kinetics was studied using Fick�s law. The kinetic study revealed that polymeric matrices showed the value of n as n > 1.0, hence drug release took place by non-Fickian diffusion. Hence, the present novel findings showed the multidirectional drug release rate. The morphological changes due to interwoven network structure of the crosslinked are evident by the Scanning electron microscopy (SEM) analysis. � 2022 by the authors. Licensee MDPI, Basel, Switzerland. Final 2023-05-29T09:37:51Z 2023-05-29T09:37:51Z 2022 Article 10.3390/ma15072404 2-s2.0-85127543547 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127543547&doi=10.3390%2fma15072404&partnerID=40&md5=f6725410ac935958d7d7fa755d632c73 https://irepository.uniten.edu.my/handle/123456789/26926 15 7 2404 All Open Access, Gold, Green MDPI Scopus |
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| description |
Acrylic monomers; Ascorbic acid; Chitosan; Controlled drug delivery; Graft copolymers; Grafting (chemical); Hydrogels; Scanning electron microscopy; Sodium; Targeted drug delivery; Acrylamides; Crosslinked; Diclofenac sodium; Drug release; Equilibration process; Fick�s law; Graft- copolymers; PH-responsive; Sodium diclofenac; Sustainable drug release; Amides |
| author2 |
57422629500 |
| author_facet |
57422629500 Chopra L. Thakur K.K. Chohan J.S. Sharma S. Ilyas R.A. Asyraf M.R.M. Zakaria S.Z.S. |
| format |
Article |
| author |
Chopra L. Thakur K.K. Chohan J.S. Sharma S. Ilyas R.A. Asyraf M.R.M. Zakaria S.Z.S. |
| spellingShingle |
Chopra L. Thakur K.K. Chohan J.S. Sharma S. Ilyas R.A. Asyraf M.R.M. Zakaria S.Z.S. Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers |
| author_sort |
Chopra L. |
| title |
Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers |
| title_short |
Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers |
| title_full |
Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers |
| title_fullStr |
Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers |
| title_full_unstemmed |
Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers |
| title_sort |
comparative drug release investigations for diclofenac sodium drug (ds) by chitosan-based grafted and crosslinked copolymers |
| publisher |
MDPI |
| publishDate |
2023 |
| _version_ |
1806427729312088064 |
| score |
13.214268 |