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Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells

One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon...

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Main Authors: Fadaeinasab, M., Karimian, H., Omar, H., Taha, H., khorasani, A., Banisalam, B., Aziz Ketuly, K., Abdullah, Z.
Format: Article
Language:English
Published: 2020
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spelling my.uniten.dspace-133142020-03-16T08:53:51Z Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells Fadaeinasab, M. Karimian, H. Omar, H. Taha, H. khorasani, A. Banisalam, B. Aziz Ketuly, K. Abdullah, Z. One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC 50 value of 30.24 ± 0.75 µM. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. 2020-02-03T03:31:46Z 2020-02-03T03:31:46Z 2019 Article 10.1080/10286020.2019.1588888 en
institution Universiti Tenaga Nasional
building UNITEN Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tenaga Nasional
content_source UNITEN Institutional Repository
url_provider http://dspace.uniten.edu.my/
language English
description One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC 50 value of 30.24 ± 0.75 µM. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
format Article
author Fadaeinasab, M.
Karimian, H.
Omar, H.
Taha, H.
khorasani, A.
Banisalam, B.
Aziz Ketuly, K.
Abdullah, Z.
spellingShingle Fadaeinasab, M.
Karimian, H.
Omar, H.
Taha, H.
khorasani, A.
Banisalam, B.
Aziz Ketuly, K.
Abdullah, Z.
Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells
author_facet Fadaeinasab, M.
Karimian, H.
Omar, H.
Taha, H.
khorasani, A.
Banisalam, B.
Aziz Ketuly, K.
Abdullah, Z.
author_sort Fadaeinasab, M.
title Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells
title_short Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells
title_full Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells
title_fullStr Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells
title_full_unstemmed Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells
title_sort reflexin a, a new indole alkaloid from rauvolfia reflexa induces apoptosis against colon cancer cells
publishDate 2020
_version_ 1662758844995993600
score 13.214268

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