Mechanism of Action of Camptothecin
Camptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. Their molecular target has been firmly established to be human DNA topoisomerase I (topo I). CPT inhibits topo I by blocking the rejoining step of the cleavage/religation reaction of topo-...
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| Main Authors: | , , , , , |
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| Format: | E-Article |
| Published: |
Annals of the New York Academy of Sciences
2006
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/8233/ http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2000.tb07020.x/abstract;jsessionid=8077573930C275ADC499C4011810F5D6.f02t03?userIsAuthenticated=false&deniedAccessCustomisedMessage= |
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