Substituted benzo[i]phenanthridines as mammalian topoisomerase-Targeting agents

• Main Authors: Makhey, D., Li, D., Zhao, B., Sim, S.P, Li, TK, Liu, A., Liu, L.F., LaVoie, E.J.
• Format: E-Article
• Language: English
• Published: Elsevier Ltd 2003
• Subjects: QD Chemistry; R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/2485/1/Substituted%20benzo%5Bi%5Dphenanthridines%20as%20mammalian%20topoisomerase-Targeting%20agents.pdf; http://ir.unimas.my/id/eprint/2485/

Several benzo[c]phenanthridine and protoberberine alkaloids, such as nitidine and berberrubine, are known to induce DNA cleavage in the presence of either topoisomerase I or II. Structure–activity studies performed on various analogues related to benzo[c]phenanthridine and protoberberine alkaloids h...