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Isolation and characterization of the ribosomal protein gene, RPL37A, from human nasopharyngeal-derived cell lines

Previous studies have shown that expression of RPL37A gene was downregulated in nasopharyngeal carcinoma cell lines and it had been reported that genetic mutation of coding sequences in ribosomal protein gene RPSJ9 is the cause of dysregulation of gene expression in Diamond-Blackfan Anemia. The o...

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Main Author: Kiung, Siong Siang
Format: Final Year Project Report
Language:English
Published: Universiti Malaysia Sarawak, (UNIMAS) 2012
Subjects:
QM Human anatomy
Online Access:http://ir.unimas.my/id/eprint/8211/11/Kiung%20Siong%20Siang%20%28full%29.pdf
http://ir.unimas.my/id/eprint/8211/
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spelling my.unimas.ir.82112023-08-11T03:29:36Z http://ir.unimas.my/id/eprint/8211/ Isolation and characterization of the ribosomal protein gene, RPL37A, from human nasopharyngeal-derived cell lines Kiung, Siong Siang QM Human anatomy Previous studies have shown that expression of RPL37A gene was downregulated in nasopharyngeal carcinoma cell lines and it had been reported that genetic mutation of coding sequences in ribosomal protein gene RPSJ9 is the cause of dysregulation of gene expression in Diamond-Blackfan Anemia. The objective of this study is to determine whether mutation in coding sequences of RPL37A gene is the cause of its differential expression in nasopharyngeal carcinoma by isolating, sequencing and analyzing the coding sequences of the gene from normal nasopharyngeal epithelial cell lines and nasopharyngeal carcinoma cell lines. Results from this study show that there is no difference in the nucleotide sequence in the coding region of RPL37A gene from both types of nasopharyngeal cell lines and therefore indicates that mutation in the coding region of the RPL37A gene is not the cause of its differential expression in nasopharyngeal carcinoma. Universiti Malaysia Sarawak, (UNIMAS) 2012 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/8211/11/Kiung%20Siong%20Siang%20%28full%29.pdf Kiung, Siong Siang (2012) Isolation and characterization of the ribosomal protein gene, RPL37A, from human nasopharyngeal-derived cell lines. [Final Year Project Report] (Unpublished)
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic QM Human anatomy
spellingShingle QM Human anatomy
Kiung, Siong Siang
Isolation and characterization of the ribosomal protein gene, RPL37A, from human nasopharyngeal-derived cell lines
description Previous studies have shown that expression of RPL37A gene was downregulated in nasopharyngeal carcinoma cell lines and it had been reported that genetic mutation of coding sequences in ribosomal protein gene RPSJ9 is the cause of dysregulation of gene expression in Diamond-Blackfan Anemia. The objective of this study is to determine whether mutation in coding sequences of RPL37A gene is the cause of its differential expression in nasopharyngeal carcinoma by isolating, sequencing and analyzing the coding sequences of the gene from normal nasopharyngeal epithelial cell lines and nasopharyngeal carcinoma cell lines. Results from this study show that there is no difference in the nucleotide sequence in the coding region of RPL37A gene from both types of nasopharyngeal cell lines and therefore indicates that mutation in the coding region of the RPL37A gene is not the cause of its differential expression in nasopharyngeal carcinoma.
format Final Year Project Report
author Kiung, Siong Siang
author_facet Kiung, Siong Siang
author_sort Kiung, Siong Siang
title Isolation and characterization of the ribosomal protein gene, RPL37A, from human nasopharyngeal-derived cell lines
title_short Isolation and characterization of the ribosomal protein gene, RPL37A, from human nasopharyngeal-derived cell lines
title_full Isolation and characterization of the ribosomal protein gene, RPL37A, from human nasopharyngeal-derived cell lines
title_fullStr Isolation and characterization of the ribosomal protein gene, RPL37A, from human nasopharyngeal-derived cell lines
title_full_unstemmed Isolation and characterization of the ribosomal protein gene, RPL37A, from human nasopharyngeal-derived cell lines
title_sort isolation and characterization of the ribosomal protein gene, rpl37a, from human nasopharyngeal-derived cell lines
publisher Universiti Malaysia Sarawak, (UNIMAS)
publishDate 2012
url http://ir.unimas.my/id/eprint/8211/11/Kiung%20Siong%20Siang%20%28full%29.pdf
http://ir.unimas.my/id/eprint/8211/
_version_ 1775627182262976512
score 13.154949

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