Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia.

• Main Authors: Hang, Vu Thi Ty, Holmes, Edward C., Veasna, Duong, Quy, Nguyen Thien, Hien, Tran Tinh, Quail, Michael, Churcher, Carol, Parkhill, Julian, Cardosa, Mary Jane, Farrar, Jeremy, Wills, Bridget, Lennon, Niall J., Birren, Bruce W., Buchy, Philippe, Henn, Matthew R., Simmons, Cameron P.
• Format: E-Article
• Language: English
• Published: PLOS 2010
• Subjects: Q Science (General); QR355 Virology; R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/7008/1/Emergence%20of%20the%20Asian%201%20Genotype%20of%20Dengue%20Virus%20Serotype%202%20in%20Viet%20Nam_%20In%20Vivo%20Fitness%20Advantage%20and%20Lineage%20Replacement%20in%20South-East%20Asia.pdf; http://ir.unimas.my/id/eprint/7008/; http://www.ncbi.nlm.nih.gov/pubmed/20651932

A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control. To this end we determined the complete coding region sequence of 187 DENV-2 genomes and 68 E genes from viruses sampled from Vietnamese patients betwee...