Heterogeneous Patterns of Endothelial NF-κB p65 and MAPK c-Jun Activation, Adhesion Molecule Expression, and Leukocyte Recruitment in Lung Microvasculature of Mice with Sepsis

• Main Authors: Zhendong, Wang, Dayang Erna Zulaikha, Awang Hamsin, Peter J., Zwiers, Martha L., Hernandez Garcia, Matthijs, Luxen, Jill, Moser, Jan A.A.M, Kamps, Grietje, Molema
• Format: Article
• Language: English
• Published: MDPI 2024
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://ir.unimas.my/id/eprint/45420/1/biomedicines-12-01672.pdf; http://ir.unimas.my/id/eprint/45420/; https://www.mdpi.com/2227-9059/12/8/1672#:~:text=In%20summary%2C%20in%20mouse%20lungs,expression%2C%20nor%20with%20leukocyte%20recruitment.; https://doi.org/10.3390/biomedicines12081672

Sepsis is an uncontrolled systemic inflammatory response to an infection that can result in acute failure of the function of the lung called acute respiratory distress syndrome. Leukocyte recruitment is an important hallmark of acute lung failure in patients with sepsis. Endothelial cells (EC) parti...