Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after stopping tyrosine kinase inhibitor in chronic myeloid leukaemia patients with deep molecular response for at least two years
Fluctuation of BCR-ABL1 real-time quantitative polymerase chain reaction in International Scale (qPCRIS ) level below major molecular response (MMR) (0.1%IS ) is a known phenomenon after stopping tyrosine kinase inhibitor (TKI) in chronic myeloid leukaemia (CML) patients who are attempting tr...
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2021
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| Online Access: | http://ir.unimas.my/id/eprint/37246/1/myeloid1.pdf http://ir.unimas.my/id/eprint/37246/ https://pubmed.ncbi.nlm.nih.gov/34031342/ |
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my.unimas.ir.372462021-12-16T08:19:18Z http://ir.unimas.my/id/eprint/37246/ Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after stopping tyrosine kinase inhibitor in chronic myeloid leukaemia patients with deep molecular response for at least two years Kuan, Jew-Win Chang, Kian-Meng Chin, Lee Phan Wong, Shu Ping Lim, Soo Min Toh, See Guan Loh, Weng Khean R Medicine (General) RD Surgery Fluctuation of BCR-ABL1 real-time quantitative polymerase chain reaction in International Scale (qPCRIS ) level below major molecular response (MMR) (0.1%IS ) is a known phenomenon after stopping tyrosine kinase inhibitor (TKI) in chronic myeloid leukaemia (CML) patients who are attempting treatment free remission (TFR). We report here four cases of fluctuation beyond MMR during conduct of a Malaysia Stop TKI Trial (MSIT) to examine the validity of the commonly used relapse criterion – loss of MMR for one reading – aiming to provide evidence in setting relapse criteria for future CML patients who want to attempt TFR. NCBI Literature Resources 2021-05 Article PeerReviewed text en http://ir.unimas.my/id/eprint/37246/1/myeloid1.pdf Kuan, Jew-Win and Chang, Kian-Meng and Chin, Lee Phan and Wong, Shu Ping and Lim, Soo Min and Toh, See Guan and Loh, Weng Khean (2021) Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after stopping tyrosine kinase inhibitor in chronic myeloid leukaemia patients with deep molecular response for at least two years. Medical Journal of Malaysia, 76 (3). pp. 414-416. ISSN 0300-5283 https://pubmed.ncbi.nlm.nih.gov/34031342/ |
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R Medicine (General) RD Surgery |
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R Medicine (General) RD Surgery Kuan, Jew-Win Chang, Kian-Meng Chin, Lee Phan Wong, Shu Ping Lim, Soo Min Toh, See Guan Loh, Weng Khean Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after stopping tyrosine kinase inhibitor in chronic myeloid leukaemia patients with deep molecular response for at least two years |
| description |
Fluctuation of BCR-ABL1 real-time quantitative polymerase
chain reaction in International Scale (qPCRIS
) level below
major molecular response (MMR) (0.1%IS
) is a known
phenomenon after stopping tyrosine kinase inhibitor (TKI) in
chronic myeloid leukaemia (CML) patients who are
attempting treatment free remission (TFR). We report here
four cases of fluctuation beyond MMR during conduct of a
Malaysia Stop TKI Trial (MSIT) to examine the validity of the
commonly used relapse criterion – loss of MMR for one
reading – aiming to provide evidence in setting relapse
criteria for future CML patients who want to attempt TFR. |
| format |
Article |
| author |
Kuan, Jew-Win Chang, Kian-Meng Chin, Lee Phan Wong, Shu Ping Lim, Soo Min Toh, See Guan Loh, Weng Khean |
| author_facet |
Kuan, Jew-Win Chang, Kian-Meng Chin, Lee Phan Wong, Shu Ping Lim, Soo Min Toh, See Guan Loh, Weng Khean |
| author_sort |
Kuan, Jew-Win |
| title |
Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after
stopping tyrosine kinase inhibitor in chronic myeloid
leukaemia patients with deep molecular response for at
least two years |
| title_short |
Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after
stopping tyrosine kinase inhibitor in chronic myeloid
leukaemia patients with deep molecular response for at
least two years |
| title_full |
Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after
stopping tyrosine kinase inhibitor in chronic myeloid
leukaemia patients with deep molecular response for at
least two years |
| title_fullStr |
Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after
stopping tyrosine kinase inhibitor in chronic myeloid
leukaemia patients with deep molecular response for at
least two years |
| title_full_unstemmed |
Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after
stopping tyrosine kinase inhibitor in chronic myeloid
leukaemia patients with deep molecular response for at
least two years |
| title_sort |
fluctuation of bcr-abl1 qpcris level beyond 0.1%is after
stopping tyrosine kinase inhibitor in chronic myeloid
leukaemia patients with deep molecular response for at
least two years |
| publisher |
NCBI Literature Resources |
| publishDate |
2021 |
| url |
http://ir.unimas.my/id/eprint/37246/1/myeloid1.pdf http://ir.unimas.my/id/eprint/37246/ https://pubmed.ncbi.nlm.nih.gov/34031342/ |
| _version_ |
1720440435859521536 |
| score |
13.160551 |