Fluctuation of BCR-ABL1 qPCRIS level beyond 0.1%IS after stopping tyrosine kinase inhibitor in chronic myeloid leukaemia patients with deep molecular response for at least two years
Fluctuation of BCR-ABL1 real-time quantitative polymerase chain reaction in International Scale (qPCRIS ) level below major molecular response (MMR) (0.1%IS ) is a known phenomenon after stopping tyrosine kinase inhibitor (TKI) in chronic myeloid leukaemia (CML) patients who are attempting tr...
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Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
NCBI Literature Resources
2021
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Subjects: | |
Online Access: | http://ir.unimas.my/id/eprint/37246/1/myeloid1.pdf http://ir.unimas.my/id/eprint/37246/ https://pubmed.ncbi.nlm.nih.gov/34031342/ |
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Summary: | Fluctuation of BCR-ABL1 real-time quantitative polymerase
chain reaction in International Scale (qPCRIS
) level below
major molecular response (MMR) (0.1%IS
) is a known
phenomenon after stopping tyrosine kinase inhibitor (TKI) in
chronic myeloid leukaemia (CML) patients who are
attempting treatment free remission (TFR). We report here
four cases of fluctuation beyond MMR during conduct of a
Malaysia Stop TKI Trial (MSIT) to examine the validity of the
commonly used relapse criterion – loss of MMR for one
reading – aiming to provide evidence in setting relapse
criteria for future CML patients who want to attempt TFR. |
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