Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities
A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were...
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Universiti Malaysia Sarawak, (UNIMAS)
2014
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Online Access: | http://ir.unimas.my/id/eprint/34435/2/Chai%20Tchan%20Wei%20ft.pdf http://ir.unimas.my/id/eprint/34435/ |
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my.unimas.ir.344352023-01-30T08:17:15Z http://ir.unimas.my/id/eprint/34435/ Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities Chai, Tchan Wei RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were characterised using CHN analyzer, FTIR, 1H NMR and 13C NMR spectroscopy. These synthesised compounds were screened for their antibacterial activities against Gram-negative bacteria (Escherichia Coli) using Kirby Bauer method. Among the synthesised compounds, compound 21 was inactive against E. Coli while compound 20 showed good activity against E. Coli. Universiti Malaysia Sarawak, (UNIMAS) 2014 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/34435/2/Chai%20Tchan%20Wei%20ft.pdf Chai, Tchan Wei (2014) Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities. [Final Year Project Report] (Unpublished) |
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RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine Chai, Tchan Wei Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities |
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A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were characterised using CHN analyzer, FTIR, 1H NMR and 13C NMR spectroscopy. These synthesised compounds were screened for
their antibacterial activities against Gram-negative bacteria (Escherichia Coli) using Kirby Bauer method. Among the synthesised compounds, compound 21 was inactive against E.
Coli while compound 20 showed good activity against E. Coli. |
format |
Final Year Project Report |
author |
Chai, Tchan Wei |
author_facet |
Chai, Tchan Wei |
author_sort |
Chai, Tchan Wei |
title |
Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities |
title_short |
Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities |
title_full |
Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities |
title_fullStr |
Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities |
title_full_unstemmed |
Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities |
title_sort |
synthesis of aspirin-thiourea derivatives and their antibacterial activities |
publisher |
Universiti Malaysia Sarawak, (UNIMAS) |
publishDate |
2014 |
url |
http://ir.unimas.my/id/eprint/34435/2/Chai%20Tchan%20Wei%20ft.pdf http://ir.unimas.my/id/eprint/34435/ |
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1756688314101923840 |
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13.18916 |