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Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities

A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were...

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Bibliographic Details
Main Author: Chai, Tchan Wei
Format: Final Year Project Report
Language:English
Published: Universiti Malaysia Sarawak, (UNIMAS) 2014
Subjects:
RS Pharmacy and materia medica
RV Botanic, Thomsonian, and eclectic medicine
Online Access:http://ir.unimas.my/id/eprint/34435/2/Chai%20Tchan%20Wei%20ft.pdf
http://ir.unimas.my/id/eprint/34435/
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spelling my.unimas.ir.344352023-01-30T08:17:15Z http://ir.unimas.my/id/eprint/34435/ Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities Chai, Tchan Wei RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were characterised using CHN analyzer, FTIR, 1H NMR and 13C NMR spectroscopy. These synthesised compounds were screened for their antibacterial activities against Gram-negative bacteria (Escherichia Coli) using Kirby Bauer method. Among the synthesised compounds, compound 21 was inactive against E. Coli while compound 20 showed good activity against E. Coli. Universiti Malaysia Sarawak, (UNIMAS) 2014 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/34435/2/Chai%20Tchan%20Wei%20ft.pdf Chai, Tchan Wei (2014) Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities. [Final Year Project Report] (Unpublished)
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic RS Pharmacy and materia medica
RV Botanic, Thomsonian, and eclectic medicine
spellingShingle RS Pharmacy and materia medica
RV Botanic, Thomsonian, and eclectic medicine
Chai, Tchan Wei
Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities
description A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were characterised using CHN analyzer, FTIR, 1H NMR and 13C NMR spectroscopy. These synthesised compounds were screened for their antibacterial activities against Gram-negative bacteria (Escherichia Coli) using Kirby Bauer method. Among the synthesised compounds, compound 21 was inactive against E. Coli while compound 20 showed good activity against E. Coli.
format Final Year Project Report
author Chai, Tchan Wei
author_facet Chai, Tchan Wei
author_sort Chai, Tchan Wei
title Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities
title_short Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities
title_full Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities
title_fullStr Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities
title_full_unstemmed Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities
title_sort synthesis of aspirin-thiourea derivatives and their antibacterial activities
publisher Universiti Malaysia Sarawak, (UNIMAS)
publishDate 2014
url http://ir.unimas.my/id/eprint/34435/2/Chai%20Tchan%20Wei%20ft.pdf
http://ir.unimas.my/id/eprint/34435/
_version_ 1756688314101923840
score 13.18916

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