Synthesis of Aspirin-Thiourea Derivatives and Their Antibacterial Activities
A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were...
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| Main Author: | |
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| Format: | Final Year Project Report |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2014
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| Online Access: | http://ir.unimas.my/id/eprint/34435/2/Chai%20Tchan%20Wei%20ft.pdf http://ir.unimas.my/id/eprint/34435/ |
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| Summary: | A series of aspirin-thiourea derivatives 18-21 were synthesised by reacting acetylsalicyloyl chloride with KSCN to produce acetoxybenzoyl isothiocyanate, following with 2,3-d imethylaniline, 2,4-dimethylaniline, 2,5-dimethylaniline and 2,6-dimethylaniline respectively. The synthesised compounds were characterised using CHN analyzer, FTIR, 1H NMR and 13C NMR spectroscopy. These synthesised compounds were screened for
their antibacterial activities against Gram-negative bacteria (Escherichia Coli) using Kirby Bauer method. Among the synthesised compounds, compound 21 was inactive against E.
Coli while compound 20 showed good activity against E. Coli. |
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