Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site
Reported cases of Mycobacterium tuberculosis (Mtb) infection in Pongo pygmaeus (Bornean orangutan) have been alarming as threat. The present study looks on the pharmacophore modelling of the Mtb active site (from Protein Data Bank, PDB) with the conventional tuberculosis regimens such as rifampin,...
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Universiti Malaysia Sarawak, (UNIMAS)
2014
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my.unimas.ir.328932023-10-19T08:40:26Z http://ir.unimas.my/id/eprint/32893/ Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site Ho, Ket Wah Q Science (General) Reported cases of Mycobacterium tuberculosis (Mtb) infection in Pongo pygmaeus (Bornean orangutan) have been alarming as threat. The present study looks on the pharmacophore modelling of the Mtb active site (from Protein Data Bank, PDB) with the conventional tuberculosis regimens such as rifampin, isoniazid, pyrazinamide, ethambutol and streptomycin and potential tuberculosis regimens include fluoroquinolones and diarylquinoline. Pharmacophore modelling was performed using Ligandscout 3.10 to search the potential tuberculosis regimen using structure based. Screening among the seven regimens used, only four regimens which are ethambutol, rifampin, streptomycin and fluoroquinolones have shared similar features to generate phamarcophore with Mtb active site. Universiti Malaysia Sarawak, (UNIMAS) 2014 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/32893/2/Ho%20Ket%20Wah.pdf Ho, Ket Wah (2014) Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site. [Final Year Project Report] (Unpublished) |
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Q Science (General) Ho, Ket Wah Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site |
description |
Reported cases of Mycobacterium tuberculosis (Mtb) infection in Pongo pygmaeus (Bornean orangutan) have
been alarming as threat. The present study looks on the pharmacophore modelling of the Mtb active site (from
Protein Data Bank, PDB) with the conventional tuberculosis regimens such as rifampin, isoniazid, pyrazinamide,
ethambutol and streptomycin and potential tuberculosis regimens include fluoroquinolones and diarylquinoline.
Pharmacophore modelling was performed using Ligandscout 3.10 to search the potential tuberculosis regimen
using structure based. Screening among the seven regimens used, only four regimens which are ethambutol,
rifampin, streptomycin and fluoroquinolones have shared similar features to generate phamarcophore with Mtb
active site. |
format |
Final Year Project Report |
author |
Ho, Ket Wah |
author_facet |
Ho, Ket Wah |
author_sort |
Ho, Ket Wah |
title |
Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site |
title_short |
Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site |
title_full |
Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site |
title_fullStr |
Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site |
title_full_unstemmed |
Prediction Of Catalytic Ethanol Acid Residue Of Mth (Mycobacterium Tuberculosis) Active Site |
title_sort |
prediction of catalytic ethanol acid residue of mth (mycobacterium tuberculosis) active site |
publisher |
Universiti Malaysia Sarawak, (UNIMAS) |
publishDate |
2014 |
url |
http://ir.unimas.my/id/eprint/32893/2/Ho%20Ket%20Wah.pdf http://ir.unimas.my/id/eprint/32893/ |
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1781710307797762048 |
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13.160551 |