Oxidant Production, oxLDL uptake and CD36 levels in Human Monocyte Derived Macrophages are down regulated by the macrophage - generated antioxidant 7,8-dihydroneopterin

• Main Authors: Gieseg, S.P, Zunika, Amit, Ya, T.Y, Shchepetkina, A., Katouah, H.
• Format: Article
• Language: English
• Published: Mary Ann Liebert, INC 2010
• Subjects: Q Science (General); R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/2449/1/Oxidant%20Production...pdf; http://ir.unimas.my/id/eprint/2449/; https://www.liebertpub.com/doi/10.1089/ars.2009.3065

The severity of atheroma burden in patients strongly correlates to increasing levels of plasma neopterin, the oxidation product of 7,8-dihydroneopterin. Interferon-γ stimulation of macrophages causes the synthesis of 7,8-dihydroneopterin, a potent antioxidant that inhibits oxidative damage to cells,...