MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay_a case control study

• Main Authors: Hayati, AR, Zainal, AI, Tan, G.C, Ong, L.C, Khoo, T.B
• Format: E-Article
• Language: English
• Published: Med J Malaysia 2008
• Subjects: Q Science (General); R Medicine (General); RB Pathology
• Online Access: http://ir.unimas.my/id/eprint/2260/1/MTHFR%20C677T%20polymorphism%20as%20a%20risk%20factor%20of%20neural%20tube%20defects%20in%20Malay_a%20case%20control%20study.pdf; http://ir.unimas.my/id/eprint/2260/

Major congenital malformations occur in about 3% of newborn. Several studies have suggested that homozygosity for the C677T methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs). It has been hypothesized that the maternal folic acid supplementa...