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Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death

In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the pos...

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Main Authors: Octavio, Carvajal-Zarrabal, Patricia M., Hayward-Jones, Cirilo Nolasco, Nolasco-Hipólito, Dulce, Barradas-Dermitz, Ana Laura, Calderón-Garcidueñas, Noe, Lopez-Amador
Format: E-Article
Published: Blackwell Publishing Inc. 2017
Subjects:
TP Chemical technology
Online Access:http://ir.unimas.my/id/eprint/17878/
http://onlinelibrary.wiley.com/doi/10.1111/1556-4029.13397/full
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spelling my.unimas.ir.178782017-10-02T07:05:32Z http://ir.unimas.my/id/eprint/17878/ Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death Octavio, Carvajal-Zarrabal Patricia M., Hayward-Jones Cirilo Nolasco, Nolasco-Hipólito Dulce, Barradas-Dermitz Ana Laura, Calderón-Garcidueñas Noe, Lopez-Amador TP Chemical technology In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (P <0.05). SCD cases showed significantly higher levels (P <0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 hours of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD. Blackwell Publishing Inc. 2017 E-Article PeerReviewed Octavio, Carvajal-Zarrabal and Patricia M., Hayward-Jones and Cirilo Nolasco, Nolasco-Hipólito and Dulce, Barradas-Dermitz and Ana Laura, Calderón-Garcidueñas and Noe, Lopez-Amador (2017) Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death. Journal of Forensic Sciences, 62 (5). pp. 1332-1335. ISSN 0022-1198 http://onlinelibrary.wiley.com/doi/10.1111/1556-4029.13397/full DOI: 10.1111/1556-4029.13397
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Octavio, Carvajal-Zarrabal
Patricia M., Hayward-Jones
Cirilo Nolasco, Nolasco-Hipólito
Dulce, Barradas-Dermitz
Ana Laura, Calderón-Garcidueñas
Noe, Lopez-Amador
Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
description In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponin I and T (cTn-T & T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (P <0.05). SCD cases showed significantly higher levels (P <0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 hours of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD.
format E-Article
author Octavio, Carvajal-Zarrabal
Patricia M., Hayward-Jones
Cirilo Nolasco, Nolasco-Hipólito
Dulce, Barradas-Dermitz
Ana Laura, Calderón-Garcidueñas
Noe, Lopez-Amador
author_facet Octavio, Carvajal-Zarrabal
Patricia M., Hayward-Jones
Cirilo Nolasco, Nolasco-Hipólito
Dulce, Barradas-Dermitz
Ana Laura, Calderón-Garcidueñas
Noe, Lopez-Amador
author_sort Octavio, Carvajal-Zarrabal
title Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_short Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_full Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_fullStr Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_full_unstemmed Use of Cardiac Injury Markers in the Postmortem Diagnosis of Sudden Cardiac Death
title_sort use of cardiac injury markers in the postmortem diagnosis of sudden cardiac death
publisher Blackwell Publishing Inc.
publishDate 2017
url http://ir.unimas.my/id/eprint/17878/
http://onlinelibrary.wiley.com/doi/10.1111/1556-4029.13397/full
_version_ 1644512730316537856
score 13.160551

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