Bis-Thiourea bearing aryl and amino acids side Chains and their antibacterial activities

• Main Authors: Wan Sharifatun Handayani, Wan Zullkiplee, Ainaa Nadiah, Abd Halim, Zainab, Ngaini, Maya Asyikin, Mohd Ariff, Hasnain, Hussain
• Format: Article
• Language: English
• Published: Taylor & Francis Group, LLC 2016
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://ir.unimas.my/id/eprint/15566/1/BIS-THIOUREA.pdf; http://ir.unimas.my/id/eprint/15566/; https://www.researchgate.net/publication/263286084_Bis-Thiourea_Bearing_Aryl_and_Amino_Acids_Side_Chains_and_Their_Antibacterial_Activities

A series of symmetrical 1,3-bis thiourea 1a–e and 1,4-bis thiourea derivatives 2a–e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectroscopy and 1H and 13C NMR spectroscopy. The compounds were screened for their antibacterial activity by turbidimetric method using gram-negative bacteria (E. coli ATCC 8739) using turbidimetric method. The newly synthesized bis-thiourea derivatives bearing aryl side chains showed good antibacterial activity against E. coli. The effect of the molecular structure of the synthesized compounds on the antibacterial activity is discussed.