Bis-Thiourea bearing aryl and amino acids side Chains and their antibacterial activities
A series of symmetrical 1,3-bis thiourea 1a–e and 1,4-bis thiourea derivatives 2a–e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectros...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group, LLC
2016
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/15566/1/BIS-THIOUREA.pdf http://ir.unimas.my/id/eprint/15566/ https://www.researchgate.net/publication/263286084_Bis-Thiourea_Bearing_Aryl_and_Amino_Acids_Side_Chains_and_Their_Antibacterial_Activities |
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| Summary: | A series of symmetrical 1,3-bis thiourea 1a–e and 1,4-bis thiourea derivatives 2a–e have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectroscopy and 1H and 13C NMR spectroscopy. The compounds were screened for their antibacterial activity by turbidimetric method using gram-negative bacteria (E. coli ATCC 8739) using turbidimetric method. The newly synthesized bis-thiourea
derivatives bearing aryl side chains showed good antibacterial activity against E. coli. The
effect of the molecular structure of the synthesized compounds on the antibacterial activity is
discussed. |
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