Topological radiogenomics based on persistent lifetime images for identification of epidermal growth factor receptor mutation in patients with non-small cell lung tumors

• Main Authors: Takumi, Kodama, Hidetaka, Arimura, Tomoki, Tokuda, Kentaro, Tanaka, Hidetake, Yabuuchi, Nadia Fareeda, Muhammad Gowdh, Liam, Chong Kin, Chai, Chee Shee, Ng, Kwan Hoong
• Format: Article
• Language: English
• Published: Elsevier 2025
• Subjects: R Medicine (General); RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://ir.unimas.my/id/eprint/47290/1/Topological%20radiogenomics%20based%20on%20persistent%20lifetime%20images%20for%20identification%20of%20epidermal%20growth%20factor%20receptor%20mutation%20in%20patients%20with%20non-small%20cell%20lung%20tumors.pdf; http://ir.unimas.my/id/eprint/47290/; https://www.sciencedirect.com/science/article/pii/S0010482524016044; https://doi.org/10.1016/j.compbiomed.2024.109519

We hypothesized that persistent lifetime (PLT) images could represent tumor imaging traits, locations, and persistent contrasts of topological components (connected and hole components) corresponding to gene mutations such as epidermal growth factor receptor (EGFR) mutant signs. We aimed to develop...