Three-dimensional topological radiogenomics of epidermal growth factor receptor Del19 and L858R mutation subtypes on computed tomography images of lung cancer patients

• Main Authors: Kenta, Ninomiya, Hidetaka, Arimura, Kentaro, Tanaka, Chan, Wai Yee, Yutaro, Kabata, Shinichi, Mizuno, Nadia Fareeda, Muhammad Gowdh, Nur Adura, Yaakup, Liam, Chong Kin, Chai, Chee Shee, Ng, Kwan Hoong
• Format: Article
• Language: English
• Published: ELSEVIER 2023
• Subjects: R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/41725/1/Three-dimensional%20topological%20radiogenomics%20of%20epidermal%20growth%20factor%20receptor%20Del19%20and%20L858R%20mutation%20subtypes%20on%20computed%20tomography%20images%20of%20lung%20cancer%20patients%20-%20ScienceDirect.pdf; http://ir.unimas.my/id/eprint/41725/; https://www.sciencedirect.com/science/article/abs/pii/S0169260723002092; https://doi.org/10.1016/j.cmpb.2023.107544

Objectives : To elucidate a novel radiogenomics approach using three-dimensional (3D) topologically invariant Betti numbers (BNs) for topological characterization of epidermal growth factor receptor (EGFR) Del19 and L858R mutation subtypes. Methods : In total, 154 patients (wild-type EGFR, 72 p...