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Fabrication of silicon nitride ion sensitive field-effect transistor for pH measurement and DNA immobilization/hybridization

Link to publisher's homepage at http://www.hindawi.com/

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Bibliographic Details
Main Authors: Uda, Hashim, Prof. Dr., Soon, Weng Chong, Liu, Wei Wen, Dr.
Other Authors: uda@unimap.edu.my
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2014
Subjects:
Ag/AgCl electrodes
DNA hybridization
DNA immobilization
pH measurement
Online Access:http://dspace.unimap.edu.my:80/dspace/handle/123456789/33165
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spelling my.unimap-331652014-03-27T07:23:03Z Fabrication of silicon nitride ion sensitive field-effect transistor for pH measurement and DNA immobilization/hybridization Uda, Hashim, Prof. Dr. Soon, Weng Chong Liu, Wei Wen, Dr. uda@unimap.edu.my soonweng86@gmail.com wwliu@unimap.edu.my Ag/AgCl electrodes DNA hybridization DNA immobilization pH measurement Link to publisher's homepage at http://www.hindawi.com/ The fabrication of ion sensitive field-effect transistor (ISFET) using silicon nitride (Si3N4) as the sensing membrane for pH measurement and DNA is reported. For the pH measurement, the Ag/AgCl electrode was used as the reference electrode, and different pH values of buffer solution were used in the ISFET analysis. The ISFET device was tested with pH buffer solutions of pH2, pH3, pH7, pH8, and pH9. The results show that the IV characteristic of ISFET devices is directly proportional and the device's sensitivity was 43.13 mV/pH. The ISFET is modified chemically to allow the integration with biological element to form a biologically active field-effect transistor (BIOFET). It was found that the DNA immobilization activities which occurred on the sensing membrane caused the drain current to drop due to the negatively charged backbones of the DNA probes repelled electrons from accumulating at the conducting channel. The drain current was further decreased when the DNA hybridization took place. 2014-03-27T07:23:03Z 2014-03-27T07:23:03Z 2013 Article Journal of Nanomaterials, vol. 2013, 2013, pages 1-9 1687-4110 http://www.hindawi.com/journals/jnm/2013/542737/ http://dspace.unimap.edu.my:80/dspace/handle/123456789/33165 en Hindawi Publishing Corporation
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Ag/AgCl electrodes
DNA hybridization
DNA immobilization
pH measurement
spellingShingle Ag/AgCl electrodes
DNA hybridization
DNA immobilization
pH measurement
Uda, Hashim, Prof. Dr.
Soon, Weng Chong
Liu, Wei Wen, Dr.
Fabrication of silicon nitride ion sensitive field-effect transistor for pH measurement and DNA immobilization/hybridization
description Link to publisher's homepage at http://www.hindawi.com/
author2 uda@unimap.edu.my
author_facet uda@unimap.edu.my
Uda, Hashim, Prof. Dr.
Soon, Weng Chong
Liu, Wei Wen, Dr.
format Article
author Uda, Hashim, Prof. Dr.
Soon, Weng Chong
Liu, Wei Wen, Dr.
author_sort Uda, Hashim, Prof. Dr.
title Fabrication of silicon nitride ion sensitive field-effect transistor for pH measurement and DNA immobilization/hybridization
title_short Fabrication of silicon nitride ion sensitive field-effect transistor for pH measurement and DNA immobilization/hybridization
title_full Fabrication of silicon nitride ion sensitive field-effect transistor for pH measurement and DNA immobilization/hybridization
title_fullStr Fabrication of silicon nitride ion sensitive field-effect transistor for pH measurement and DNA immobilization/hybridization
title_full_unstemmed Fabrication of silicon nitride ion sensitive field-effect transistor for pH measurement and DNA immobilization/hybridization
title_sort fabrication of silicon nitride ion sensitive field-effect transistor for ph measurement and dna immobilization/hybridization
publisher Hindawi Publishing Corporation
publishDate 2014
url http://dspace.unimap.edu.my:80/dspace/handle/123456789/33165
_version_ 1643797086675664896
score 13.214268

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