New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants

• Main Authors: Straathof, A. J. J., Heijnen, J. J.
• Format: Article
• Language: English
• Published: John Wiley & Sons, Inc. 2008
• Subjects: Enzyme kinetics.; Parameter estimation.
• Online Access: http://dspace.unimap.edu.my/xmlui/handle/123456789/1503

For an enzymatic reaction the rate constants in the assumed mechanism (k1,k_1, etc.)sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring among the steady-state parameters. This redundancy is only partly revealed by the known Haldane relations. We found th...