Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats
This study assessed the toxicity of lutein-rich purple sweet potato leaf (PSPL) extract in male Sprague–Dawley rats. Methods and study design: A total of 54 adult male Sprague–Dawley rats were used. For the acute toxicity study, three rats in the acute control group were fed 2,000 mg/kg of PSPL for...
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Frontiers Media S.A.
2023
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my.ums.eprints.386022024-05-02T08:46:51Z https://eprints.ums.edu.my/id/eprint/38602/ Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats Ahmad Safiyyu’d-din Bin Hisamuddin Ruth Naomi Khairul Aiman Manan Hasnah Bahari Muhammad Dain Yazid Fezah Othman Hashim Embong Siti Hadizah Jumidil Mohd Khairi Hussain Zainul Amiruddin Zakaria QK1-989 Botany RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) This study assessed the toxicity of lutein-rich purple sweet potato leaf (PSPL) extract in male Sprague–Dawley rats. Methods and study design: A total of 54 adult male Sprague–Dawley rats were used. For the acute toxicity study, three rats in the acute control group were fed 2,000 mg/kg of PSPL for 14 days. The subacute toxicity study included six rats each in four groups administered 50, 250, 500, or 1,000 mg/kg for 28 days and observed for further 14 days without treatment in the subacute control and subacute satellite groups. Changes in body weight; blood biochemistry; hematological parameters; relative organ weight; and histological sections of the heart, kidney, liver, pancreas, aorta, and retina were observed for signs of toxicity. Results: The gradual increase in weekly body weight, normal level full blood count, normal liver and kidney profile, relative organ weight, and histological sections of all stained organ tissue in the treated group compared with the acute, subacute, and satellite control groups demonstrated the absence of signs of toxicity. Conclusion: Lutein-rich PSPL extract shows no signs of toxicity up to 2,000 mg/kg/day. Frontiers Media S.A. 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/38602/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/38602/2/FULL%20TEXT.pdf Ahmad Safiyyu’d-din Bin Hisamuddin and Ruth Naomi and Khairul Aiman Manan and Hasnah Bahari and Muhammad Dain Yazid and Fezah Othman and Hashim Embong and Siti Hadizah Jumidil and Mohd Khairi Hussain and Zainul Amiruddin Zakaria (2023) Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats. Frontiers in Pharmacology, 14. pp. 1-12. ISSN 1666-9812 https://doi.org/10.3389/fphar.2023.1132087 |
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QK1-989 Botany RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Ahmad Safiyyu’d-din Bin Hisamuddin Ruth Naomi Khairul Aiman Manan Hasnah Bahari Muhammad Dain Yazid Fezah Othman Hashim Embong Siti Hadizah Jumidil Mohd Khairi Hussain Zainul Amiruddin Zakaria Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats |
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This study assessed the toxicity of lutein-rich purple sweet potato leaf (PSPL) extract in male Sprague–Dawley rats. Methods and study design: A total of 54 adult male Sprague–Dawley rats were used. For the acute toxicity study, three rats in the acute control group were fed 2,000 mg/kg of PSPL for 14 days. The subacute toxicity study included six rats each in four groups administered 50, 250, 500, or 1,000 mg/kg for 28 days and observed for further 14 days without treatment in the subacute control and subacute satellite groups. Changes in body weight; blood biochemistry; hematological parameters; relative organ weight; and histological sections of the heart, kidney, liver, pancreas, aorta, and retina were observed for signs of toxicity. Results: The gradual increase in weekly body weight, normal level full blood count, normal liver and kidney profile, relative organ weight, and histological sections of all stained organ tissue in the treated group compared with the acute, subacute, and satellite control groups demonstrated the absence of signs of toxicity. Conclusion: Lutein-rich PSPL extract shows no signs of toxicity up to 2,000 mg/kg/day. |
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Ahmad Safiyyu’d-din Bin Hisamuddin Ruth Naomi Khairul Aiman Manan Hasnah Bahari Muhammad Dain Yazid Fezah Othman Hashim Embong Siti Hadizah Jumidil Mohd Khairi Hussain Zainul Amiruddin Zakaria |
author_facet |
Ahmad Safiyyu’d-din Bin Hisamuddin Ruth Naomi Khairul Aiman Manan Hasnah Bahari Muhammad Dain Yazid Fezah Othman Hashim Embong Siti Hadizah Jumidil Mohd Khairi Hussain Zainul Amiruddin Zakaria |
author_sort |
Ahmad Safiyyu’d-din Bin Hisamuddin |
title |
Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats |
title_short |
Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats |
title_full |
Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats |
title_fullStr |
Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats |
title_full_unstemmed |
Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats |
title_sort |
phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male sprague–dawley rats |
publisher |
Frontiers Media S.A. |
publishDate |
2023 |
url |
https://eprints.ums.edu.my/id/eprint/38602/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38602/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/38602/ https://doi.org/10.3389/fphar.2023.1132087 |
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