Matrix metalloproteinases in chemoresistance: regulatory roles, molecular interactions, and potential inhibitors

• Main Authors: Xin, Bernadette Jie Tune, Maw, Shin Sim, Chit, Laa Poh, Rhanye Mac Guad, Choy, Ker Woon, Iswar Hazarika, Anju Das, Subash C. B. Gopinath, Mariappan Rajan, Mahendran Sekar, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria, Kalaivani Batumalaie, Yuan, Seng Wu
• Format: Article
• Language: English; English
• Published: Hindawi Publishing 2022
• Subjects: RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
• Online Access: https://eprints.ums.edu.my/id/eprint/33751/1/Matrix%20metalloproteinases%20in%20chemoresistance_%20regulatory%20roles%2C%20molecular%20interactions%2C%20and%20potential%20inhibitors.pdf; https://eprints.ums.edu.my/id/eprint/33751/2/Matrix%20metalloproteinases%20in%20chemoresistance_%20regulatory%20roles%2C%20molecular%20interactions%2C%20and%20potential%20inhibitors%20_ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/33751/; https://downloads.hindawi.com/journals/jo/2022/3249766.pdf; https://doi.org/10.1155/2022/3249766

Cancer is one of the major causes of death worldwide. Its treatments usually fail when the tumor has become malignant and metastasized. Metastasis is a key source of cancer recurrence, which often leads to resistance towards chemotherapeutic agents. Hence, most cancer-related deaths are linked to th...