Cytotoxic sesquiterpenoids from soft coral Capnella imbricata

• Main Authors: Phan, Chin Soon, Takashi Kamada, Takahiro Ishii, Toshiyuki Hamada, Charles Santhanaraju Vairappan
• Format: Article
• Language: English; English
• Published: 2019
• Subjects: SH Aquaculture. Fisheries. Angling
• Online Access: https://eprints.ums.edu.my/id/eprint/25474/1/Cytotoxic%20sesquiterpenoids%20from%20soft%20coral%20Capnella%20imbricata.pdf; https://eprints.ums.edu.my/id/eprint/25474/2/Cytotoxic%20sesquiterpenoids%20from%20soft%20coral%20Capnella%20imbricata%201.pdf; https://eprints.ums.edu.my/id/eprint/25474/; https://doi.org/10.1177/1934578X19857494

A new sesquiterpene, capgermacrene H (1) was isolated together with 7 other compounds, capgermacrenes A-G (2-8), from a population of soft coral Capnella imbricata collected from Mantanani Island, Sabah, Malaysia. The structure of this metabolite was elucidated based on spectroscopic data such as nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry. Capgermacrene A (2) showed potent cytotoxicity against adult T-cell leukemia, S1T cells at half-maximal inhibitory concentration of 0.79 µg/mL.