Cytotoxic sesquiterpenoids from soft coral Capnella imbricata
A new sesquiterpene, capgermacrene H (1) was isolated together with 7 other compounds, capgermacrenes A-G (2-8), from a population of soft coral Capnella imbricata collected from Mantanani Island, Sabah, Malaysia. The structure of this metabolite was elucidated based on spectroscopic data such as nu...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/25474/1/Cytotoxic%20sesquiterpenoids%20from%20soft%20coral%20Capnella%20imbricata.pdf https://eprints.ums.edu.my/id/eprint/25474/2/Cytotoxic%20sesquiterpenoids%20from%20soft%20coral%20Capnella%20imbricata%201.pdf https://eprints.ums.edu.my/id/eprint/25474/ https://doi.org/10.1177/1934578X19857494 |
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| Summary: | A new sesquiterpene, capgermacrene H (1) was isolated together with 7 other compounds, capgermacrenes A-G (2-8), from a population of soft coral Capnella imbricata collected from Mantanani Island, Sabah, Malaysia. The structure of this metabolite was elucidated based on spectroscopic data such as nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry. Capgermacrene A (2) showed potent cytotoxicity against adult T-cell leukemia, S1T cells at half-maximal inhibitory concentration of 0.79 µg/mL. |
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