Impact of the SAC : CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization

• Main Authors: Khairool Azizul, Mohammad, Wei, Michelle Ho Siaw, Engku Nuraishah Huda, Engku Zainudin, Syarifah, Abd Rahim
• Format: Article
• Language: English; English
• Published: Springer Science and Business Media B.V. 2024
• Subjects: QD Chemistry; T Technology (General); TA Engineering (General). Civil engineering (General); TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/42128/1/Impact%20of%20the%20SAC_CBZ%20ratio%20on%20polymorphic%20transformation.pdf; http://umpir.ump.edu.my/id/eprint/42128/2/Impact%20of%20the%20SAC_CBZ%20ratio%20on%20polymorphic%20transformation%20and%20morphology%20of%20carbamazepine-saccharin%20co-crystals%20using%20fast%20cooling%20crystallization_ABS.pdf; http://umpir.ump.edu.my/id/eprint/42128/; https://doi.org/10.1007/s10973-024-13379-y; https://doi.org/10.1007/s10973-024-13379-y

Carbamazepine-saccharin (CBZ-SAC) co-crystal is one of the most studied co-crystals to date. It is proven to be polymorphic, consisting of Form I (plate-like shape) and Form II (needle-like shape), which is rarely reported by researchers. The present study aimed to study the effect of SAC:CBZ ratio...