Impact of the SAC:CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization

• Main Authors: Mohammad, Khairool Azizul, Wei, Michelle H. S., Zainudin, Engku Nur Aisha Huda, Abd Rahim, Syarifah
• Format: Article
• Language: English; English; English
• Published: Springer 2024
• Subjects: RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/117633/1/117633_Impact%20of%20the%20SAC%20CBZ%20ratio%20on%20polymorphic%20transformation.pdf; http://irep.iium.edu.my/117633/2/117633_Impact%20of%20the%20SAC%20CBZ%20ratio%20on%20polymorphic%20transformation_Scopus.pdf; http://irep.iium.edu.my/117633/13/117633_Impact%20of%20the%20SAC%20CBZ%20ratio%20on%20polymorphic%20transformation_WoS.pdf; http://irep.iium.edu.my/117633/; https://link.springer.com/article/10.1007/s10973-024-13379-y; https://doi.org/10.1007/s10973-024-13379-y

Carbamazepine-saccharin (CBZ-SAC) co-crystal is one of the most studied co-crystals to date. It is proven to be polymorphic, consisting of Form I (plate-like shape) and Form II (needle-like shape), which is rarely reported by researchers. The present study aimed to study the effect of SAC:CBZ ratio...