Induction of apoptosis and regulation ofMicroRNA expression by (2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)- cyclohexanone (BHMC) treatment on MCF-7 breast cancer cells

• Main Authors: Yeap, S. K., Ali, N. M., Akhtar, M. N., Razak, N. A., Chong, Z. X., Ho, W. Y., Boo, L., Zareen, S., Kurniawan, T. A., Avtar, R., Ng, S. Y. L., Ong, A. H. K.
• Format: Article
• Language: English
• Published: MDPI AG 2021
• Subjects: RC Internal medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer); T Technology (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/32769/1/Induction%20of%20apoptosis%20and%20regulation%20ofMicroRNA%20expression%20by%20%282E%2C6E%29-2%2C6-bis-%284-hydroxy-3-methoxybenzylidene%29-%20cyclohexanone%20%28BHMC%29%20treatment.pdf; http://umpir.ump.edu.my/id/eprint/32769/; https://doi.org/10.3390/molecules26051277; https://doi.org/10.3390/molecules26051277

(2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) is a synthetic curcumin analogue, which has been reported to possess anti-tumor, anti-metastatic, and anti-invasion properties on estrogen receptor (ER) negative breast cancer cells in vitro and in vivo. However, the cytotoxic eff...