Induction of apoptosis and regulation of MicroRNA expression by (2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) treatment on MCF-7 breast cancer cells

• Main Authors: Yeap, Swee Keong, Norlaily, Mohd Ali, Akhtar, Muhammad Nadeem, Nursyamirah, Abd Razak, Chong, Zhi Xiong, Ho, Wan Yong, Boo, Lily, Seema, Zareen, Tonni Agustiono, Kurniawan, Avtar, Ram, Ng, Stephanie Y. L., Ong, Alan Han Kiat, Alitheen, Noorjahan Banu
• Format: Article
• Language: English
• Published: MDPI - Open Access Publishing 2021
• Subjects: TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/31831/1/Induction%20of%20apoptosis%20and%20regulation%20of%20microRNA%20expression.pdf; http://umpir.ump.edu.my/id/eprint/31831/; https://doi.org/10.3390/molecules26051277; https://doi.org/10.3390/molecules26051277

(2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) is a synthetic curcumin analogue, which has been reported to possess anti-tumor, anti-metastatic, and anti-invasion properties on estrogen receptor (ER) negative breast cancer cells in vitro and in vivo. However, the cytotoxic eff...