Self-assembled insulin and nanogels polyelectrolyte complex (Ins/NGs-PEC) for oral insulin delivery: Characterization, lyophilization and in-vivo evaluation

• Main Authors: Mudassir, Jahanzeb, Yusrida, Darwis, Suriani, Muhamad, Khan, Arshad Ali
• Format: Article
• Language: English
• Published: Dovepress 2019
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology; TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/27329/1/Self-assembled%20insulin%20and%20nanogels%20polyelectrolyte%20complex.pdf; http://umpir.ump.edu.my/id/eprint/27329/; https://doi.org/10.2147/IJN.S199507; https://doi.org/10.2147/IJN.S199507

Introduction: Insulin is given by injection, because when administered orally, it would be destroyed by enzymes in the digestive system, hence only about 0.1% reaches blood circulation. The purpose of the present study was to use pH sensitive polyelectrolyte methyl methacrylate (MMA)/itaconic acid (...