Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro

• Main Authors: Nadiah, Abu, M. Nadeem, Akhtar, Yeap, Swee Keong, Lim, Kian Lam, Ho, Wan Yong, Aimi Jamil, Zulfadli, Abdul Rahman, Omar, Mohd Roslan, Sulaiman, Mohd Puad, Abdullah, Noorjahan Banu, Alitheen
• Format: Article
• Language: English
• Published: Public Library of Science 2014
• Subjects: Q Science (General)
• Online Access: http://umpir.ump.edu.my/id/eprint/25416/1/Flavokawain%20a%20induces%20apoptosis%20in%20MCF-7%20and%20MDA-MB231.PDF; http://umpir.ump.edu.my/id/eprint/25416/; https://doi.org/10.1371/journal.pone.0105244; https://doi.org/10.1371/journal.pone.0105244

The kava-kava plant (Piper methsyticum) is traditionally known as the pacific elixir by the pacific islanders for its role in a wide range of biological activities. The extract of the roots of this plant contains a variety of interesting molecules including Flavokawain A and this molecule is known to have anti-cancer properties. Breast cancer is still one of the leading diagnosed cancers in women today. The metastatic process is also very pertinent in the progression of tumorigenesis.