Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro

• Main Authors: Abu, N., Akhtar, M.N., Yeap, S.K., Lim, K.L., Ho, W.Y., Abdullah, M.P., Ho, C.L., Omar, A.R., Ismail, J., Alitheen, N.B.
• Format: Article
• Language: English
• Published: BioMed Central 2016
• Subjects: Q Science (General)
• Online Access: http://eprints.um.edu.my/18030/1/Abu%2C_N._%282016%29.pdf; http://eprints.um.edu.my/18030/; https://doi.org/10.1186/s12906-016-1046-8

Background: The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mecha...