Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine
This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coa...
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my.ump.umpir.247482019-04-19T07:59:46Z http://umpir.ump.edu.my/id/eprint/24748/ Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine Trinh Duy, Nguyen Hieu, Vu-Quang Thanh, Sang Vo Duy, Chinh Nguyen Dai-Viet, N. Vo Dai Hai, Nguyen Kwon, Taek Lim Dai, Lam Tran Long, Giang Bach QD Chemistry TP Chemical technology This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coated CdTe QDs, synthesized using 2-mercaptoethanol (ME) as a capping agent, were coupled with a RAFT agent, S-benzyl S′ trimethoxysilylpropyltrithiocarbonate (BTPT), through a condensation reaction. Then, 2,2′-azobisisobutyronitrile (AIBN) was used to successfully initiate in situ RAFT polymerization to generate PPEGMA-g-CdTe nanocomposites. Adenosine-above-PPEGMA-grafted CdTe (Ado-i-PPEGMA-g-CdTe) hybrids were formed by the polymer shell, which had successfully undergone bioconjugation and postfunctionalization by adenosine (as a nucleoside). Fourier transform infrared (FT-IR) spectrophotometry, energy-dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy results indicated that a robust covalent bond was created between the organic PPEGMA part, cadmium telluride (CdTe) QDs, and the adenosine conjugate. The optical properties of the PPEGMA-g-CdTe and Ado-i-PPEGMA-g-CdTe hybrids were investigated by photoluminescence (PL) spectroscopy, and the results suggest that they have a great potential for application as optimal materials in biomedicine. MDPI 2019-01-06 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24748/1/Chemical%20Synthesis%20and%20Characterization%20of.pdf Trinh Duy, Nguyen and Hieu, Vu-Quang and Thanh, Sang Vo and Duy, Chinh Nguyen and Dai-Viet, N. Vo and Dai Hai, Nguyen and Kwon, Taek Lim and Dai, Lam Tran and Long, Giang Bach (2019) Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine. Polymers, 11 (1). pp. 1-12. ISSN 2073-4360 https://doi.org/10.3390/polym11010077 https://doi.org/10.3390/polym11010077 |
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QD Chemistry TP Chemical technology Trinh Duy, Nguyen Hieu, Vu-Quang Thanh, Sang Vo Duy, Chinh Nguyen Dai-Viet, N. Vo Dai Hai, Nguyen Kwon, Taek Lim Dai, Lam Tran Long, Giang Bach Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine |
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This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coated CdTe QDs, synthesized using 2-mercaptoethanol (ME) as a capping agent, were coupled with a RAFT agent, S-benzyl S′ trimethoxysilylpropyltrithiocarbonate (BTPT), through a condensation reaction. Then, 2,2′-azobisisobutyronitrile (AIBN) was used to successfully initiate in situ RAFT polymerization to generate PPEGMA-g-CdTe nanocomposites. Adenosine-above-PPEGMA-grafted CdTe (Ado-i-PPEGMA-g-CdTe) hybrids were formed by the polymer shell, which had successfully undergone bioconjugation and postfunctionalization by adenosine (as a nucleoside). Fourier transform infrared (FT-IR) spectrophotometry, energy-dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy results indicated that a robust covalent bond was created between the organic PPEGMA part, cadmium telluride (CdTe) QDs, and the adenosine conjugate. The optical properties of the PPEGMA-g-CdTe and Ado-i-PPEGMA-g-CdTe hybrids were investigated by photoluminescence (PL) spectroscopy, and the results suggest that they have a great potential for application as optimal materials in biomedicine. |
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Article |
author |
Trinh Duy, Nguyen Hieu, Vu-Quang Thanh, Sang Vo Duy, Chinh Nguyen Dai-Viet, N. Vo Dai Hai, Nguyen Kwon, Taek Lim Dai, Lam Tran Long, Giang Bach |
author_facet |
Trinh Duy, Nguyen Hieu, Vu-Quang Thanh, Sang Vo Duy, Chinh Nguyen Dai-Viet, N. Vo Dai Hai, Nguyen Kwon, Taek Lim Dai, Lam Tran Long, Giang Bach |
author_sort |
Trinh Duy, Nguyen |
title |
Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine |
title_short |
Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine |
title_full |
Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine |
title_fullStr |
Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine |
title_full_unstemmed |
Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine |
title_sort |
chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted cdte nanocrystals via raft polymerization for covalent immobilization of adenosine |
publisher |
MDPI |
publishDate |
2019 |
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http://umpir.ump.edu.my/id/eprint/24748/1/Chemical%20Synthesis%20and%20Characterization%20of.pdf http://umpir.ump.edu.my/id/eprint/24748/ https://doi.org/10.3390/polym11010077 https://doi.org/10.3390/polym11010077 |
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1643669904177496064 |
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13.18916 |