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Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine

This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coa...

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Bibliographic Details
Main Authors: Trinh Duy, Nguyen, Hieu, Vu-Quang, Thanh, Sang Vo, Duy, Chinh Nguyen, Dai-Viet, N. Vo, Dai Hai, Nguyen, Kwon, Taek Lim, Dai, Lam Tran, Long, Giang Bach
Format: Article
Language:English
Published: MDPI 2019
Subjects:
QD Chemistry
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/24748/1/Chemical%20Synthesis%20and%20Characterization%20of.pdf
http://umpir.ump.edu.my/id/eprint/24748/
https://doi.org/10.3390/polym11010077
https://doi.org/10.3390/polym11010077
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Summary:This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coated CdTe QDs, synthesized using 2-mercaptoethanol (ME) as a capping agent, were coupled with a RAFT agent, S-benzyl S′ trimethoxysilylpropyltrithiocarbonate (BTPT), through a condensation reaction. Then, 2,2′-azobisisobutyronitrile (AIBN) was used to successfully initiate in situ RAFT polymerization to generate PPEGMA-g-CdTe nanocomposites. Adenosine-above-PPEGMA-grafted CdTe (Ado-i-PPEGMA-g-CdTe) hybrids were formed by the polymer shell, which had successfully undergone bioconjugation and postfunctionalization by adenosine (as a nucleoside). Fourier transform infrared (FT-IR) spectrophotometry, energy-dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy results indicated that a robust covalent bond was created between the organic PPEGMA part, cadmium telluride (CdTe) QDs, and the adenosine conjugate. The optical properties of the PPEGMA-g-CdTe and Ado-i-PPEGMA-g-CdTe hybrids were investigated by photoluminescence (PL) spectroscopy, and the results suggest that they have a great potential for application as optimal materials in biomedicine.

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