Flavokawain Derivative FLS Induced G2/M Arrest and Apoptosis on Breast Cancer MCF-7 Cell Line

• Main Authors: Norlaily, Mohd Ali, Akhtar, Muhammad Nadeem, Huynh, Ky, Kian, Lam Lim, Nadiah, Abu, Seema, Zareen, Wan, Yong Ho, Han, Kiat Alan-Ong, Sheau, Wei Tan, Noorjahan Banu, Alitheen, Jamil, Ismail, Swee, Keong Yeap, Tunku, Kamarul
• Format: Article
• Language: English
• Published: Dove Medical Press 2016
• Subjects: QR Microbiology
• Online Access: http://umpir.ump.edu.my/id/eprint/16810/1/fist-2016-nadeem-Flavokawain%20derivative%20FLS2.pdf; http://umpir.ump.edu.my/id/eprint/16810/; http://dx.doi.org/10.2147/DDDT.S102164

Known as naturally occurring biologically active compounds, flavokawain A and B are the leading chalcones that possess anticancer properties. Another flavokawain derivative, (E)-1-(2′-Hydroxy-4′,6′-dimethoxyphenyl)-3-(4-methylthio)phenyl)prop-2-ene-1-one (FLS) was characterized with 1H-nuclear magne...