Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

• Main Authors: Ali, N.M., Akhtar, M.N., Ky, H., Lim, K.L., Abu, N., Zareen, S., Ho, W.Y., Alan-Ong, H.K., Tan, S.W., Alitheen, N.B., Ismail, J.B., Yeap, S.K., Kamarul, T.
• Format: Article
• Published: Dove Medical Press 2016
• Subjects: Q Science (General); R Medicine
• Online Access: http://eprints.um.edu.my/18234/; https://doi.org/10.2147/DDDT.S102164

Known as naturally occurring biologically active compounds, flavokawain A and B are the leading chalcones that possess anticancer properties. Another flavokawain derivative, (E)-1-(2′-Hydroxy-4′,6′-dimethoxyphenyl)-3-(4-methylthio)phenyl)prop-2-ene-1-one (FLS) was characterized with 1H-nuclear magne...