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Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro

Background The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mec...

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Main Authors: Nadiah, Abu, Akhtar, Muhammad Nadeem, Swee, K. Yeap, Kian, Lam Lim, Wan, Yong Ho, Mohd Puad, Abdullah, Chai, Ling Ho, Abdul Rahman, Omar, Jamil, Ismail, Noorjahan Banu, Alitheen
Format: Article
Language:English
Published: BioMed Central Ltd. 2016
Subjects:
QR Microbiology
Online Access:http://umpir.ump.edu.my/id/eprint/16809/1/fist-2016-nadeem-Flavokawain%20B%20induced1.pdf
http://umpir.ump.edu.my/id/eprint/16809/
http://doi.org/10.1186/s12906-016-1046-8
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spelling my.ump.umpir.168092017-11-17T06:46:29Z http://umpir.ump.edu.my/id/eprint/16809/ Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro Nadiah, Abu Akhtar, Muhammad Nadeem Swee, K. Yeap Kian, Lam Lim Wan, Yong Ho Mohd Puad, Abdullah Chai, Ling Ho Abdul Rahman, Omar Jamil, Ismail Noorjahan Banu, Alitheen QR Microbiology Background The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mechanism of the anti-cancer activity of a synthetic Flavokawain B (FKB) on two breast cancer cell lines, MCF-7 and MDA-MB231 was investigated. BioMed Central Ltd. 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16809/1/fist-2016-nadeem-Flavokawain%20B%20induced1.pdf Nadiah, Abu and Akhtar, Muhammad Nadeem and Swee, K. Yeap and Kian, Lam Lim and Wan, Yong Ho and Mohd Puad, Abdullah and Chai, Ling Ho and Abdul Rahman, Omar and Jamil, Ismail and Noorjahan Banu, Alitheen (2016) Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro. BMC Complementary and Alternative Medicine, 16 (86). pp. 1-14. ISSN 1472-6882 http://doi.org/10.1186/s12906-016-1046-8 doi: 10.1186/s12906-016-1046-8
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic QR Microbiology
spellingShingle QR Microbiology
Nadiah, Abu
Akhtar, Muhammad Nadeem
Swee, K. Yeap
Kian, Lam Lim
Wan, Yong Ho
Mohd Puad, Abdullah
Chai, Ling Ho
Abdul Rahman, Omar
Jamil, Ismail
Noorjahan Banu, Alitheen
Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro
description Background The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mechanism of the anti-cancer activity of a synthetic Flavokawain B (FKB) on two breast cancer cell lines, MCF-7 and MDA-MB231 was investigated.
format Article
author Nadiah, Abu
Akhtar, Muhammad Nadeem
Swee, K. Yeap
Kian, Lam Lim
Wan, Yong Ho
Mohd Puad, Abdullah
Chai, Ling Ho
Abdul Rahman, Omar
Jamil, Ismail
Noorjahan Banu, Alitheen
author_facet Nadiah, Abu
Akhtar, Muhammad Nadeem
Swee, K. Yeap
Kian, Lam Lim
Wan, Yong Ho
Mohd Puad, Abdullah
Chai, Ling Ho
Abdul Rahman, Omar
Jamil, Ismail
Noorjahan Banu, Alitheen
author_sort Nadiah, Abu
title Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro
title_short Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro
title_full Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro
title_fullStr Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro
title_full_unstemmed Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro
title_sort flavokawain b induced cytotoxicity in two breast cancer cell lines, mcf-7 and mda-mb231 and inhibited the metastatic potential of mda-mb231 via the regulation of several tyrosine kinases in vitro
publisher BioMed Central Ltd.
publishDate 2016
url http://umpir.ump.edu.my/id/eprint/16809/1/fist-2016-nadeem-Flavokawain%20B%20induced1.pdf
http://umpir.ump.edu.my/id/eprint/16809/
http://doi.org/10.1186/s12906-016-1046-8
_version_ 1643668018088116224
score 13.209306

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