Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways

• Main Authors: Looi, C.Y., Moharram, B., Paydar, M., Wong, Y.L., Leong, K.H., Mohamad, K., Arya, A., Wong, W.F., Mustafa, Mohd Rais
• Format: Article
• Language: English
• Published: BioMed Central 2013
• Subjects: R Medicine; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/9804/1/Induction_of_apoptosis_in_melanoma_A375.pdf; http://eprints.um.edu.my/9804/; http://www.biomedcentral.com/1472-6882/13/166/

Background: Centratherum anthelminticum (L.) Kuntze (scientific synonyms: Vernonia anthelmintica; black cumin) is one of the ingredients of an Ayurvedic preparation, called Kayakalpâ, commonly applied to treat skin disorders in India and Southeast Asia. Despite its well known anti-inflammatory prope...