Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach

• Main Authors: Moschidou, D., Mukherjee, S., Blundell, M.P., Drews, K., Jones, G.N., Abdulrazzak, H., Nowakowska, B., Phoolchund, A., Lay, K., Ramasamy, T.S., Cananzi, M., Nettersheim, D., Sullivan, M., Frost, J., Moore, G., Vermeesch, J.R., Fisk, N.M., Thrasher, A.J., Atala, A., Adjaye, J., Schorle, H., De Coppi, P., Guillot, P.V.
• Format: Article
• Published: 2012
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/9244/

Induced pluripotent stem cells (iPSCs) with potential for therapeutic applications can be derived from somatic cells via ectopic expression of a set of limited and defined transcription factors. However, due to risks of random integration of the reprogramming transgenes into the host genome, the low...