DNA methylation profiling revealed prometer hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma

• Main Authors: Khor, G.H., Froemming, G.R.A., Zain, R.B., Abraham, M.T., Omar, E., Tan, S.K., Tan, A.C.
• Format: Article
• Language: English
• Published: 2013
• Subjects: RK Dentistry
• Online Access: http://eprints.um.edu.my/9127/1/v10p1727.pdf; http://eprints.um.edu.my/9127/

Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis, and therapeutic treatment of oral squamous cel...