DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma

• Main Authors: Khor, Goot Heah, Froemming, Gabriele Ruth Anisah, Zain, R.B., Abraham, Mannil Thomas, Omar, Effat, Tan, Su Keng, Tan, Aik Choon, Chong, Vincent Vui King, Thong, Kwai Lin
• Format: Article
• Language: English
• Published: Ivyspring International Publisher 2013
• Subjects: Q Science (General); QH Natural history; RK Dentistry
• Online Access: http://eprints.um.edu.my/10644/1/Khor%2C_2013.pdf; http://eprints.um.edu.my/10644/; http://www.medsci.org/v10p1727.htm

BACKGROUND: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis, and therapeutic treatment of oral squamous ce...