Alpha-tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate carcinoma Pc-3 cells is accompanied by inactivation of nuclear factor-kappa b signaling

• Main Authors: Lee, S.T., Wong, P.F., He, H., Hooper, J.D., Mustafa, Mohd Rais
• Format: Article
• Language: English
• Published: Public Library of Science 2013
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/8249/1/Lee-2013-Alpha-Tomatine_Atten.pdf; http://eprints.um.edu.my/8249/

Background: Nuclear factor-kappa B (NF-κB) plays a role in prostate cancer and agents that suppress its activation may inhibit development or progression of this malignancy. Alpha (α)-tomatine is the major saponin present in tomato (Lycopersicon esculentum) and we have previously reported that it...