7 alpha-Hydroxy-beta-Sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular Bax/Bcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK1/2 Activation

• Main Authors: Tasyriq, Mohammad, Najmuldeen, Ibrahim A., In, Lionel L.A., Mohamad, Khalit, Awang, Khalijah, Nagoor, Noor Hasima
• Format: Article
• Language: English
• Published: Hindawi 2012
• Subjects: QH301 Biology
• Online Access: http://eprints.um.edu.my/7783/1/7_alpha-Hydroxy-beta-Sitosterol_from_Chisocheton_tomentosus_Induces_Apoptosis_via_Dysregulation_of_Cell.pdf; http://eprints.um.edu.my/7783/; https://doi.org/10.1155/2012/765316

In continuation of our interest towards the elucidation of apoptotic pathways of cytotoxic phytocompounds, we have embarked upon a study on the anticancer effects of 7 alpha-hydroxy-beta-sitosterol (CT1), a rare natural phytosterol oxide isolated from Chisocheton tomentosus. CT1 was found to be cyto...